Wnt signalling is one of the most important signalling networks in development and homeostasis. Wnt malfunction is implicated in various forms of disease, including cancer and degenerative diseases. Activation of this signalling networks relies on proper dissemination of Wnt proteins in a tissue. Albeit 30 years of Wnt research, we still do not understand how the distribution of signalling molecules is controlled. However, this knowledge is important because it will open up completely new strategies to control Wnt signalling in development, regeneration and diseases by altering its transport route. Recently we have shown that extracellular Wnt trafficking requires signalling filopodia called cytonemes in vertebrates. Our mission is to understand the molecular mechanism controlling cytoneme emergence to allow Wnt proteins transport through a vertebrate tissue over hundreds of micrometres and to establish an effective signalling gradient.
Home » Research
And the award for best Christmas jumper this year goes to... Nic! 🎄🎄🎄☃️⛄️🍾
From all of us here at #LSIExeter, season's greetings and happy holidays everyone! (Many thanks Amanda for the festive photos.)
New social media project: #LSIExeter finally gets an upgrade to @LSI_Exeter! 👈 Follow for latest news, events, and job adverts!
1. Multiscale coordination of #cilia, supervised by me and @JekelyLab ...
2. Spatiotemporal dynamics of microsporidian infection, supervised by @DaumLaboratory, @BryonyWilliam18 and myself.
Check out many more from great colleagues at #LSIExeter!
And Austin's Directorship starts off with the creation of a new international PhD program! Choose from great projects (which give a flavour of the exciting interdisciplinary research happening at #LSIExeter!), or propose your own! @UniofExeter
Link --> https://t.co/pAzb5kjwmo https://t.co/vZ8uyUcoXa