{"id":31,"date":"2019-12-18T16:23:16","date_gmt":"2019-12-18T16:23:16","guid":{"rendered":"http:\/\/blogs.exeter.ac.uk\/biospec\/?page_id=31"},"modified":"2025-07-11T16:08:47","modified_gmt":"2025-07-11T15:08:47","slug":"in-vivo-raman-probes","status":"publish","type":"page","link":"https:\/\/sites.exeter.ac.uk\/biospec\/techniques\/in-vivo-raman-probes\/","title":{"rendered":"In Vivo Raman Probes"},"content":{"rendered":"\n
\n
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\"\"
Raman Needle probe<\/figcaption><\/figure><\/div><\/div>\n\n\n\n
\n
\"RaPIDE<\/a>
Raman endoscopic Probe<\/figcaption><\/figure><\/div><\/div>\n<\/div>\n\n\n\n

We have developed two devices for in vivo<\/em> use: an endoscopic probe that fits down the endoscope instrument channel, and a needle probe for targeting tissue through the skin.<\/p>\n\n\n\n

Endoscopic Probe<\/h2>\n\n\n\n

A miniature confocal probe has been designed to measure the surface of the oesophagus in vivo<\/em>.<\/p>\n\n\n\n

The device is currently undergoing trials on human patients at Gloucestershire Hospitals NHS Foundation Trust.<\/p>\n\n\n\n

For further details, please visit: rapide-diagnostics.co.uk<\/a> <\/p>\n\n\n\n

Needle Probe<\/h2>\n\n\n\n

By fixing optical fibres inside a hypodermic needle, we can acquire Raman spectra of tissues inside the human body and avoid the current standard of invasive surgery to obtain a biopsy from the patient. This \u201coptical biopsy\u201d allows for faster recovery times and an instant diagnosis. Typically, conventional biopsies are sent away for histopathological analysis, which can take time and add to patient anxiety. Conventional analysis of the stained, excised sections is performed by pathologists. They often struggle to identify early-stage tumours and results are subjective.<\/p>\n\n\n\n

Raman spectroscopy has been shown to identify and distinguish between lymphomas and metastasises ex vitro<\/em>, and we aim to develop a commercial probe to perform this in vivo<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"

We have developed two devices for in vivo use: an endoscopic probe that fits down the endoscope instrument channel, and a needle probe for targeting tissue through the skin. Endoscopic Probe A miniature confocal probe has been designed to measure the surface of the oesophagus in vivo. The device is currently undergoing trials on human […]<\/p>\n","protected":false},"author":1119,"featured_media":0,"parent":39,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-sidebar-boxed-feature-img.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"acf":[],"yoast_head":"\nIn Vivo Raman Probes - BioSpec<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.exeter.ac.uk\/biospec\/techniques\/in-vivo-raman-probes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In Vivo Raman Probes - BioSpec\" \/>\n<meta property=\"og:description\" content=\"We have developed two devices for in vivo use: an endoscopic probe that fits down the endoscope instrument channel, and a needle probe for targeting tissue through the skin. 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