{"id":343,"date":"2024-08-16T14:00:37","date_gmt":"2024-08-16T14:00:37","guid":{"rendered":"https:\/\/sites.exeter.ac.uk\/dexacell\/?page_id=343"},"modified":"2024-11-27T08:37:48","modified_gmt":"2024-11-27T08:37:48","slug":"background","status":"publish","type":"page","link":"https:\/\/sites.exeter.ac.uk\/dexacell\/background\/","title":{"rendered":"Background"},"content":{"rendered":"\n

What research question are we are trying to answer?<\/strong>
Is the addition of oral dexamethasone to usual care in patients who present to urgent and emergency care with cellulitis effective and cost-effective in terms of reducing pain, improving quality of life, and reducing further antibiotic usage and healthcare use?<\/p>\n\n\n\n

Why is this an important question to answer?<\/strong>
Cellulitis is a common bacterial skin infection and has a major impact on patients and healthcare utilisation. Hospital treatment costs in England and Wales alone are estimated at \u00a3220 million per year (1). When patients with cellulitis attend hospital they are usually treated with antibiotics and painkillers (2). However, even with this treatment around 1 in 5 patients will later seek further treatment due to ongoing symptoms – most often this is due to pain. This can lead to additional doctors appointments, A&E visits and additional antibiotics (3). It is therefore important to look for other ways to reduce early symptoms in patients with cellulitis, particularly pain.<\/p>\n\n\n\n

There is a type of anti-inflammatory medicine called \u2018corticosteroids\u2019 that are often given to reduce inflammation and pain, improving short-term symptoms in patients with other types of infection and many other conditions. They are not currently used for the treatment of cellulitis but small research studies suggest that the addition of oral corticosteroids to antibiotics reduces pain and other symptoms, without adverse effects (4-6). Because of this, some guideline bodies recommend corticosteroids in patients with cellulitis, while others suggest further trial data is needed. A definitive clinical trial is needed to establish the costs and benefits of giving corticosteroids to patients with cellulitis by assessing outcomes that matter to patients and the health service.<\/p>\n\n\n\n

We are therefore running this large trial across multiple hospitals across England and Wales. We are aiming to recruit 450 patients to participate in the trial so that we can find out whether giving people with cellulitis a \u2018corticosteroid\u2019 called dexamethasone can:<\/p>\n\n\n\n