{"id":67,"date":"2023-08-08T16:04:26","date_gmt":"2023-08-08T16:04:26","guid":{"rendered":"https:\/\/sites.exeter.ac.uk\/morekare\/?page_id=67"},"modified":"2024-03-20T09:41:32","modified_gmt":"2024-03-20T09:41:32","slug":"background","status":"publish","type":"page","link":"https:\/\/sites.exeter.ac.uk\/morekare\/background\/","title":{"rendered":"Background"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p>Over half a million adults in the UK have a severe alcohol use disorder that requires treatment<sup>1<\/sup>. However, only 1 in 5 of these individuals access treatment &#8211; and current treatments show low success rates in stopping relapse in the long term<sup>2<\/sup>. Research suggests that ketamine may be useful in the treatment of alcohol use disorder<sup>3<\/sup>. Early research conducted in the 1980s found promising reductions in alcohol relapse rates following ketamine treatment<sup>4<\/sup>. Studies have also shown that ketamine has a fast-acting anti-depressant effect and may improve learning of new information \u2013 both of which may help prevent relapse in alcohol use disorder<sup>3,5<\/sup>. <\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>MORE-KARE will build on the findings of the previous <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1176\/appi.ajp.2021.21030277\" target=\"_blank\">KARE trial <\/a><sup>6<\/sup>. In this trial, three doses of ketamine given alongside seven sessions of therapy increased abstinence from alcohol by 16% compared with placebo (i.e. no treatment).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-1024x576.png\" alt=\"\" class=\"wp-image-315\" srcset=\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-1024x576.png 1024w, https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-300x169.png 300w, https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-768x432.png 768w, https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-1536x864.png 1536w, https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4.png 1600w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p class=\"has-small-font-size\"><strong>1<\/strong> Mekonen, T., et al., <em>Treatment rates for alcohol use disorders: a systematic review and meta-analysis.<\/em> Addiction, 2021. <strong>116<\/strong>(10): p. 2617-2634.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>2<\/strong> Witkiewitz, K., et al., <em>Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.<\/em> Alcohol Clin Exp Res, 2018. <strong>42<\/strong>(12): p. 2453-2465.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>3<\/strong> Walsh, Z.M., O.; Rootman, J.,; Golsof, S.;&nbsp; Keeler, J.;&nbsp; Marsh, B.;&nbsp; Morgan, C. , <em>Ketamine for the treatment of mental health and substance use disorders: Comprehensive systematic review.<\/em> BJPsych Open, 2022. <strong>8<\/strong>.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>4<\/strong> Krupitsky, E.M. and A.Y. Grinenko, <em>Ketamine psychedelic therapy (KPT): a review of the results of ten years of research.<\/em> J Psychoactive Drugs, 1997. <strong>29<\/strong>(2): p. 165-83.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>5 <\/strong>Ivan Ezquerra-Romano I.,\u00a0et al.,\u00a0<em>Ketamine for the treatment of addiction: evidence and potential mechanisms<\/em>.\u00a0Neuropharmacology\u00a02018; <strong>142<\/strong>:72\u201382<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>6<\/strong> Grabski, M., et al., <em>Adjunctive ketamine with relapse prevention\u2013based psychological therapy in the treatment of alcohol use disorder.<\/em> American Journal of Psychiatry, 2022. <strong>179<\/strong>(2): p. 152-162.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Over half a million adults in the UK have a severe alcohol use disorder that requires treatment1. However, only 1 in 5 of these individuals access treatment &#8211; and current treatments show low success rates in stopping relapse in the long term2. Research suggests that ketamine may be useful in the treatment of alcohol use [&hellip;]<\/p>\n","protected":false},"author":931,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Background - MORE-KARE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Background - MORE-KARE\" \/>\n<meta property=\"og:description\" content=\"Over half a million adults in the UK have a severe alcohol use disorder that requires treatment1. However, only 1 in 5 of these individuals access treatment &#8211; and current treatments show low success rates in stopping relapse in the long term2. Research suggests that ketamine may be useful in the treatment of alcohol use [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/\" \/>\n<meta property=\"og:site_name\" content=\"MORE-KARE\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-20T09:41:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-1024x576.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/\",\"url\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/\",\"name\":\"Background - MORE-KARE\",\"isPartOf\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4-1024x576.png\",\"datePublished\":\"2023-08-08T16:04:26+00:00\",\"dateModified\":\"2024-03-20T09:41:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/#primaryimage\",\"url\":\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4.png\",\"contentUrl\":\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Trees4.png\",\"width\":1600,\"height\":900},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/background\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.exeter.ac.uk\/morekare\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Background\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/#website\",\"url\":\"https:\/\/sites.exeter.ac.uk\/morekare\/\",\"name\":\"MORE-KARE\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.exeter.ac.uk\/morekare\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/#organization\",\"name\":\"MORE-KARE\",\"url\":\"https:\/\/sites.exeter.ac.uk\/morekare\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Screenshot-2023-08-09-at-07.21.56.png\",\"contentUrl\":\"https:\/\/sites.exeter.ac.uk\/morekare\/wp-content\/uploads\/sites\/237\/2023\/08\/Screenshot-2023-08-09-at-07.21.56.png\",\"width\":1470,\"height\":240,\"caption\":\"MORE-KARE\"},\"image\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/morekare\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Background - MORE-KARE","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.exeter.ac.uk\/morekare\/background\/","og_locale":"en_US","og_type":"article","og_title":"Background - MORE-KARE","og_description":"Over half a million adults in the UK have a severe alcohol use disorder that requires treatment1. 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