{"id":143,"date":"2023-10-09T10:35:35","date_gmt":"2023-10-09T10:35:35","guid":{"rendered":"https:\/\/sites.exeter.ac.uk\/multidefence\/?page_id=143"},"modified":"2023-12-13T09:57:33","modified_gmt":"2023-12-13T09:57:33","slug":"prof-mark-szczelkun-university-of-bristol","status":"publish","type":"page","link":"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/","title":{"rendered":"Prof Mark Szczelkun, University of Bristol"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"326\" height=\"423\" src=\"https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S.png\" alt=\"\" class=\"wp-image-335\" srcset=\"https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S.png 326w, https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S-231x300.png 231w\" sizes=\"(max-width: 326px) 100vw, 326px\" \/><\/figure><\/div>\n\n\n<p class=\"has-medium-font-size\">Mark (he\/him) is Professor of Biochemistry at the <a href=\"https:\/\/eur03.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fresearch-information.bris.ac.uk%2Fen%2Fpersons%2Fmark-d-szczelkun&amp;data=05%7C01%7CA.Viljoen%40exeter.ac.uk%7Cd80a60a9be934d95122a08dbb38f0cbc%7C912a5d77fb984eeeaf321334d8f04a53%7C0%7C0%7C638301199206158030%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=3Oa8KdFY2P1tos35mMO6MG89OkvrG8jUc9NekCFEbuU%3D&amp;reserved=0\" target=\"_blank\" rel=\"noreferrer noopener\">University of Bristol<\/a>.<\/p>\n\n\n\n<p>Following degrees in Biochemistry from Liverpool and Southampton Universities, Mark has spent nearly 30 years at Bristol University, and started his lab in 1998, funded by a Wellcome Trust Fellowship. The research focus of his group is the mechanistic analysis of DNA recognition and cleavage by prokaryotic defence systems such as Restriction-Modification and CRISPR.&nbsp;They use a dual experimental approach to studying DNA-protein interactions \u2013 combining single molecule microscopy (including&nbsp; magnetic tweezers, TIRF and optical tweezers) with ensemble biochemistry (including millisecond time-resolution rapid-mixing fluorescence spectroscopy, molecular biology and protein chemistry). More recently they have started using nanopore sequencing as a tool for mapping DNA cleavage and modification by defence systems.<\/p>\n\n\n\n<p><a id=\"_msocom_1\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mark (he\/him) is Professor of Biochemistry at the University of Bristol. Following degrees in Biochemistry from Liverpool and Southampton Universities, Mark has spent nearly 30 years at Bristol University, and started his lab in 1998, funded by a Wellcome Trust Fellowship. The research focus of his group is the mechanistic analysis of DNA recognition and [&hellip;]<\/p>\n","protected":false},"author":929,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Prof Mark Szczelkun, University of Bristol - Multi-layered bacterial genome defences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prof Mark Szczelkun, University of Bristol - Multi-layered bacterial genome defences\" \/>\n<meta property=\"og:description\" content=\"Mark (he\/him) is Professor of Biochemistry at the University of Bristol. Following degrees in Biochemistry from Liverpool and Southampton Universities, Mark has spent nearly 30 years at Bristol University, and started his lab in 1998, funded by a Wellcome Trust Fellowship. The research focus of his group is the mechanistic analysis of DNA recognition and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/\" \/>\n<meta property=\"og:site_name\" content=\"Multi-layered bacterial genome defences\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-13T09:57:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/\",\"url\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/\",\"name\":\"Prof Mark Szczelkun, University of Bristol - Multi-layered bacterial genome defences\",\"isPartOf\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S.png\",\"datePublished\":\"2023-10-09T10:35:35+00:00\",\"dateModified\":\"2023-12-13T09:57:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/#primaryimage\",\"url\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S.png\",\"contentUrl\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/wp-content\/uploads\/sites\/235\/2023\/09\/Mark-S.png\",\"width\":326,\"height\":423},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Prof Mark Szczelkun, University of Bristol\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/#website\",\"url\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/\",\"name\":\"Multi-layered bacterial genome defences\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sites.exeter.ac.uk\/multidefence\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prof Mark Szczelkun, University of Bristol - Multi-layered bacterial genome defences","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sites.exeter.ac.uk\/multidefence\/prof-mark-szczelkun-university-of-bristol\/","og_locale":"en_US","og_type":"article","og_title":"Prof Mark Szczelkun, University of Bristol - Multi-layered bacterial genome defences","og_description":"Mark (he\/him) is Professor of Biochemistry at the University of Bristol. 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