Multi-layered bacterial genome defences

Prof Stefano Pagliara, University of Exeter


Stefano (he/him) is an Associate Professor at the Living Systems Institute at the University of Exeter.

His lab is focused on understanding how microbial cells interact with their environment both as a community and as individual cells with an emphasis of membrane transporter regulation. Besides standard microbiology techniques and omics approaches, they develop bespoke microfluidic devices that enable to accurately control the microenvironment surrounding the cells and perform a series of functional assays on the very same individual cell. This allows them to shed light on the physiology of rare subpopulations of cells that are generally hidden in ensemble measurements on clonal populations. They apply the technology they develop for collaborative studies on antimicrobial resistance, bacterial physiology, ageing in unicellular organisms and stem cell differentiation.